BENIGN BREAST PATHOLOGY:

SCLEROSING ADENOSIS

This entity usually is seen in association with fibrocystic change. It is a descriptive diagnosis. Sclerosing means too much stroma. Adenosis means too much glandular tissue.

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Slide 73. A duct (D) is noted in this subgross slice. Several smaller ducts end with tangles of elongated ductules. One focus is delineated. This is SCLEROSING ADENOSIS. Photographed at 6.3x magnification. 
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Slide 74. This subgross slice shows a cellular focus of sclerosing adenosis. Note the rounded border, a hallmark of a benign condition. Photographed at 3.2x magnification. 
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Slide 75 The histologic appearance of three foci of sclerosing adenosis. Each is centered around a terminal duct. To the examining fingers, such foci may feel as tiny "buck shots". Photographed at 10x. 
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Slide 76. Note the distinct round border of sclerosing adenosis. Photographed at 10x magnification. 
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Slide 77. The histologic pattern depicts crowded ductules. The arrow points to a myoepithelial cell of one ductule surrounded by a thickened basement membrane. Photographed at 25x magnification. 
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Slide 78. Dense stroma is "pulling" the ductules into odd shapes. Photographed at 63x magnification. 
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Slide 79. At higher magnification, the arrow points to a myoepithelial cell. Photographed at 250x magnification. 

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